Twentyone Hotel

Via Cola Di Rienzo 23, Vaticano Prati, Rome, Italy - Halfway to Vatican
4.0 1904 reviews

Located 20 minutes' walk from Campo de' Fiori Open-Air Market, the 4-star Twentyone Hotel Rome includes 88 rooms with views of the sea. This hotel offers a charging station for electric vehicles for EUR 35 per day on site.

Location

Located in the Via Cola di Rienzo district, the Rome hotel is in proximity to the large urban square "Piazza del Popolo". Located 0.2 miles from Lepanto subway station, the Twentyone is 1 mile from Pantheon Temple. Guests of the property can get to the 17th-century Sant'Agnese in Agone Baroque Church, which is a 16-minute walk away. Flaminio city rail is 0.4 miles away, while Maria Adelaide bus stop is right near this accommodation.

Rooms

The allergy-friendly rooms are equipped with an individual safe, a flat-screen TV with satellite channels, along with a mini fridge bar and coffee/tea making facilities. Guests can take advantage of a bidet, a separate toilet, and a shower, along with a hair dryer and shower caps supplied in the bathrooms.

Food & Drinks

Le Sicilianedde is only steps away from the Twentyone Rome.

Why choose Twentyone Hotel Rome

Select room
  • Luxurious dining experience at Bistrò 21

  • Modern rooms with air conditioning

  • Central location near historical sites

  • Family-friendly room options available

Main amenities

  • Wi-Fi

  • 24-hour services

  • Express check-in/ -out

  • Fitness/Gym

  • On-site Dining

  • No Smoking

  • Child-friendly

  • Wheelchair access

  • Breakfast

  • Air conditioning

  • No pets allowed

General
  • Wi-Fi
  • 24-hour services
  • Express check-in/ -out
  • Fitness/Gym
  • On-site Dining
  • No Smoking
  • Child-friendly
  • Wheelchair access
  • Breakfast
  • Air conditioning
  • No pets allowed
1/30

Internet

  • Wi-Fi

Parking options

  • Parking

Shuttle

  • Paid airport shuttle

Activities

  • Fitness centre

Property services

  • Safe deposit box
  • 24-hour reception
  • Express check-in/ -out
  • Security
  • Luggage storage
  • Barber shop
  • Room service
  • Housekeeping
  • Laundry
  • Dry cleaning
  • Tours/Ticket assistance
  • Welcome drink

Dining options

  • In-room breakfast
  • Restaurant
  • Snack bar
  • Bar/ Lounge area
  • Packed lunches
  • Special diet menus

Business facilities

  • Fax/Photocopying

For kids

  • Cots
  • Children's buffet

Recreation

  • Garden area
  • Leisure/ TV room

For disabled guests

  • Rooms/ Facilities for disabled
  • Wheelchair access
  • Toilet for disabled
  • Bathroom for disabled

In the rooms

  • Air conditioning
  • Heating
  • Mini-bar
  • Soundproofed rooms
  • Sitting area
  • Terrace
  • Garden furniture
  • Tea and coffee facilities
  • Ironing facilities

In the bathroom

  • Free toiletries
  • Sink

Devices

  • Flat-screen TV
  • AM/FM alarm clock

Design

  • Carpeted floor

General facilities

  • Non-smoking rooms
  • Allergy-free rooms
  • Lift
  • Coffee shop
  • Smoke detectors
  • Electric vehicle charging station
  • Fire extinguishers
  • Key card access

Pets

  • No pets allowed

Important information

Check-in:
from 15:00 until 23:59
Check-out:
from 07:00 until 11:00
License number058091-ALB-00313,IT058091A1GZ5MCI9I
  • Children and extra beds
  • There are no cribs provided in a room.

Enter dates to see availability

From USD 82 per night
Check-in 23 Apr 2026
Check-out 24 Apr 2026
Guests 2 guests

Adults:

2

Children:

0

Rooms

Photos of Twentyone Hotel Rome

Location of Twentyone Hotel Rome

Via Cola Di Rienzo 23, Vaticano Prati, Rome, Italy

 -  Halfway to Vatican
Attractions
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Transportation

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    100% Verified Reviews
    Enter dates to see availability
    From USD 82 per night
    Check-in 23 Apr 2026
    Check-out 24 Apr 2026
    Guests 2 guests

    Adults:

    2

    Children:

    0

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    23 Apr 2026
    24 Apr 2026
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    Details:

    Via Cola Di Rienzo 23, Rome, Italy

    Important information
    Twentyone Hotel
    Check-in:
    from 15:00 until 23:59
    Check-out:
    from 07:00 until 11:00
    License number058091-ALB-00313,IT058091A1GZ5MCI9I
    • Children and extra beds
    • There are no cribs provided in a room.