Twentyone Hotel

Via Cola Di Rienzo 23, Vaticano Prati, Rome, Italy - Halfway to Vatican
4.0 1904 reviews

The 4-star Twentyone Hotel Rome is situated in the Vaticano Prati district, 17 minutes' stroll from Piazza di Spagna and features 88 rooms with views of the sea. This hotel offers parking for EUR 35 per day on site.

Location

Located 0.2 miles from Art Studio Cafe, the Rome hotel is within reach of the Parish basilica "Church of Santa Maria del Popolo". The Twentyone in Rome is 25 minutes' walk from the large sunny square "Piazza Venezia". There is the aqueduct-fed rococo Trevi Fountain 1.1 miles away, while Villa Borghese/Washington bus station not far from this accommodation. The hotel is 5 minutes by foot from Lepanto subway station and 10 minutes by foot from Flaminio city rail.

Rooms

The Twentyone Rome features allergy-friendly rooms appointed with climate control as well as a flat-screen TV with satellite channels. They are appointed with a writing desk, and also feature a mini fridge bar and coffee/tea making facilities. Featuring bathrobes and slippers, the private bathrooms are also equipped with a spa bathtub and a walk-in shower.

Food & Drinks

Route 66 is right near this property.

Why choose Twentyone Hotel Rome

Select room
  • Luxurious dining experience at Bistrò 21

  • Modern rooms with air conditioning

  • Central location near historical sites

  • Family-friendly room options available

Main amenities

  • Free Wi-Fi

  • 24-hour services

  • Express check-in/ -out

  • Fitness/Gym

  • On-site Dining

  • No Smoking

  • Child-friendly

  • Wheelchair access

  • Breakfast

  • Air conditioning

  • No pets allowed

General
  • Free Wi-Fi
  • 24-hour services
  • Express check-in/ -out
  • Fitness/Gym
  • On-site Dining
  • No Smoking
  • Child-friendly
  • Wheelchair access
  • Breakfast
  • Air conditioning
  • No pets allowed
1/31

Internet

  • Free Wi-Fi

Parking options

  • Parking

Shuttle

  • Paid airport shuttle

Activities

  • Fitness centre

Property services

  • Safe deposit box
  • 24-hour reception
  • Express check-in/ -out
  • Security
  • Luggage storage
  • Barber shop
  • Room service
  • Housekeeping
  • Laundry
  • Dry cleaning
  • Tours/Ticket assistance
  • Welcome drink

Dining options

  • In-room breakfast
  • Restaurant
  • Snack bar
  • Bar/ Lounge area
  • Packed lunches
  • Special diet menus

Business facilities

  • Fax/Photocopying

For kids

  • Cots
  • Children's buffet

Recreation

  • Garden area
  • Leisure/ TV room

For disabled guests

  • Rooms/ Facilities for disabled
  • Wheelchair access
  • Toilet for disabled
  • Bathroom for disabled

In the rooms

  • Air conditioning
  • Heating
  • Mini-bar
  • Soundproofed rooms
  • Sitting area
  • Terrace
  • Garden furniture
  • Tea and coffee facilities
  • Ironing facilities

In the bathroom

  • Free toiletries
  • Sink

Devices

  • Flat-screen TV
  • AM/FM alarm clock

Design

  • Carpeted floor

General facilities

  • Non-smoking rooms
  • Allergy-free rooms
  • Lift
  • Coffee shop
  • Smoke detectors
  • Electric vehicle charging station
  • Fire extinguishers
  • Key card access

Pets

  • No pets allowed

Important information

Check-in:
from 15:00 until 23:59
Check-out:
from 07:00 until 11:00
License number058091-ALB-00313,IT058091A1GZ5MCI9I
  • Children and extra beds
  • There are no cribs provided in a room.

Enter dates to see availability

From USD 82 per night
Check-in 22 Jan 2026
Check-out 23 Jan 2026
Guests 2 guests

Adults:

2

Children:

0

Rooms

Photos of Twentyone Hotel Rome

Location of Twentyone Hotel Rome

Via Cola Di Rienzo 23, Vaticano Prati, Rome, Italy

 -  Halfway to Vatican
Attractions
Great restaurants
Transportation

Places nearby

    Guest reviews of Twentyone Hotel Rome

    Write a review

    When did you travel?

    Your rating point

    Very bad
    Excellent

    Your details

    Where are you from?
    Thank you! Thank you for taking the time to share your experience. Your review will be published shortly.

    Review has not been sent.

    Please try again.

    Popular hotels in Rome

    Find your perfect hotel stay today

    Popular hotels all over the world

    Find your perfect hotel stay today

    Currency
    • USD U.S. dollar
    • EUR Euro
    • GBP Pound sterling
    • AUD Australian dollar
    • CAD Canadian dollar
    • BRL Brazilian real
    • BGN Bulgarian lev
    • CNY Chinese yuan
    • CZK Czech koruna
    • DKK Danish krone
    • HKD Hong Kong dollar
    • ILS Israeli new sheqel
    • JPY Japanese yen
    • MYR Malaysian ringgit
    • NZD New Zealand dollar
    • NOK Norwegian krone
    • PLN Polish zloty
    • RON Romanian leu
    • RUB Russian ruble
    • SAR Saudi riyal
    • SGD Singapore dollar
    • ZAR South African rand
    • KRW South Korean won
    • SEK Swedish krona
    • CHF Swiss franc
    • TRY Turkish lira
    • UAH Ukrainian hryvnia
    • THB Thai baht
    Select language
    100% Verified Reviews
    Enter dates to see availability
    From USD 82 per night
    Check-in 22 Jan 2026
    Check-out 23 Jan 2026
    Guests 2 guests

    Adults:

    2

    Children:

    0
    Check-in & out
    22 Jan 2026
    23 Jan 2026
    Guests
    2 guests
    Contact Us
    Twentyone Hotel
    Your details
    Subject:
    Message:
    Your message has been sent
    Your message was not delivered

    Details:

    Via Cola Di Rienzo 23, Rome, Italy

    Important information
    Twentyone Hotel
    Check-in:
    from 15:00 until 23:59
    Check-out:
    from 07:00 until 11:00
    License number058091-ALB-00313,IT058091A1GZ5MCI9I
    • Children and extra beds
    • There are no cribs provided in a room.